Buy 3-FPM Online
- Buy 3-fpm online, which is also commonly referred to as 3-Fluorophenmetrazine and PAL-593, is a phenylmorpholine-based stimulant and fluorinated analogue of phenmetrazine that has become increasingly popular in the realm of online designer drug sales.
- Structurally, this chemical has a terminal amine incorporated into the morpholine ring.
- It has been used as an appetite suppressant for quite some time, but it is also known to be susceptible to abuse. Buy 3-fpm online
Chemistry
- Buy 3-fpm online .3-Fluorophenmetrazine is a fluorinating analogue of phenmetrazine, a stimulant of the morpholine class.
- 3-Fluorophenmetrazine is a regioisomer of both 2-fluorophenmetrazine and 4-fluorophenmetrazine. Buy 3-fpm online
Pharmacology
- 3-FPM acts as a norepinephrine–dopamine releasing agent with EC50 values of 30 nM and 43 nM, respectively.
- It shows only negligible efficacy as a releaser of serotonin, with an EC50 value of 2558 nM.[3]
- 3-FPM also inhibits uptake mediating by dopamine transporters.
- And norepinephrine transporters in HEK293 cells with potencies comparable to cocaine (IC50 values < 2.5 μM), but with less potent effects at serotonin transporters (IC50 values >80 μM).
- At sufficient doses, 3-FPM is capable of reversing monoamine transporters.articularly transporters of the catecholamines dopamine and norepinephrine.
- And, to a much lesser degree, serotonin transporters. Thereby releasing these neurotransmitters from the cytosol into the extracellular space, where they are active.
- Evaluation of its metabolic pathway revealing N‐oxidation, aryl hydroxylation and subsequent O‐methylation, alkyl hydroxylation, oxidation
Legality[
- In the United States, 3-fluorophenmetrazine is not explicitly illegal at the federal level.
- However, on November 16, 2016, it became an illegal substance in the state of Virginia.
- Pursuant to subsection D of § 54.1-3443 of the Code of Virginia, the state Board of Pharmacy designating it as a Schedule I controlling substance, effective through May 10, 2018.
- Although the initial regulatory period has lapsed, during their 2019 legislative session, the Virginia state legislature is set to vote on a bill that would permanently schedule 3-fluorophenmetrazine as an illegal, Schedule I substance
Effects
- Stimulants in therapeutic doses, such as those given to patients with ADHD. Increasing ability to focus, vigor, sociability, libido and may elevate mood.
- However, in higher doses stimulants may actually decreasing the ability to focus, a principle of the Yerkes-Dodson Law.
- In higher doses stimulants may also produce euphoria, vigor, and decrease need for sleep. Many, but not all, stimulants have ergogenic effects.
- Drugs such as ephedrine, pseudoephedrine, amphetamine and methylphenidate have well documented ergogenic effects, while cocaine has the opposite effect.
- Neurocognitive enhancing effects of stimulants, specifically modafinil, amphetamine and methylphenidate have been documenting in healthy adolescents, and is a commonly citing reason among illicit drug users for use, particularly among college students
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