Etizolam 1Mg tablets for sale online.Etizolam (marketed under many brand names) is a thienodiazepine derivative[4] which is a benzodiazepine analog.[5] The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a thienotriazolodiazepine.[6][7]
Although a thienodiazepine, etizolam is clinically regarded as a benzodiazepine because of its mode of action via the benzodiazepine receptor and directly targeting GABAA allosteric modulator receptors.[8]
It possesses anxiolytic, amnesic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.[9]
It was patent in 1972[10] and approve for medical use in 1983.[11]
As of April 2021, the export of Etizolam has been banned in India
Medical uses
- Short-term treatment of insomnia.
- Anxiety disorders such as OCD and general anxiety disorder, mostly as a short-term medication to be use purely on an at-need basis[
Overdose
Cases of intentional suicide by overdose using etizolam in combination with GABA agonists have been report.[27][31]
Although etizolam has a lower LD50 than certain benzodiazepines, the LD50 is still far beyond the prescribe or recommend dose.
Flumazenil, a GABA antagonist agent use to reverse benzodiazepine overdoses, inhibits the effect of etizolam as
well as classical benzodiazepines such as diazepam and chlordiazepoxide.[32]
Etizolam overdose deaths are rising – for instance, the National Records of Scotland report on drug-relate deaths,
‘street’ Etizolam was a factor in (“implicate in, or potentially contribute to”) 752, or 59%, of drug-relate deaths in
Scotland in 2019. It is important to highlight that more than one drug contribute to the vast majority of the
deaths (by way of comparison, opiates and opioids were a factor in 1092, or 86%, of drug-relate deaths).[3
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